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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK2
All Species:
8.79
Human Site:
Y118
Identified Species:
19.33
UniProt:
Q9NRA0
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRA0
NP_064511.2
654
69217
Y118
S
A
A
Y
F
C
I
Y
T
Y
P
R
G
R
R
Chimpanzee
Pan troglodytes
XP_001171276
652
69465
Y118
S
A
A
Y
F
C
I
Y
T
Y
P
R
G
R
R
Rhesus Macaque
Macaca mulatta
XP_001113908
653
69532
Y117
S
A
A
Y
F
C
I
Y
T
Y
P
R
S
R
R
Dog
Lupus familis
XP_541516
663
70246
Q123
F
C
I
Y
T
Y
P
Q
G
R
R
G
G
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIA7
617
65600
R94
R
G
R
R
G
G
R
R
R
A
T
R
T
F
R
Rat
Rattus norvegicus
Q91V26
383
42400
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088560
509
55981
L44
K
E
L
L
I
Q
N
L
S
L
D
A
Q
L
S
Zebra Danio
Brachydanio rerio
Q7ZW00
422
47526
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647762
661
73852
K154
Y
V
F
A
Y
V
L
K
K
R
S
L
R
S
E
Honey Bee
Apis mellifera
XP_394823
620
69588
K111
Y
I
Y
A
Y
T
L
K
K
A
R
M
K
G
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LRB0
763
83573
G171
H
A
Y
P
I
G
K
G
S
C
G
L
S
C
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
96.6
90.8
N.A.
78.4
26.6
N.A.
N.A.
N.A.
32.8
20.4
N.A.
32.2
29.3
N.A.
N.A.
Protein Similarity:
100
96.6
97.4
92.9
N.A.
84.2
37.9
N.A.
N.A.
N.A.
46.6
34
N.A.
46.4
45.7
N.A.
N.A.
P-Site Identity:
100
100
93.3
20
N.A.
13.3
0
N.A.
N.A.
N.A.
0
0
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
100
93.3
20
N.A.
13.3
0
N.A.
N.A.
N.A.
6.6
0
N.A.
13.3
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
37
28
19
0
0
0
0
0
19
0
10
0
0
0
% A
% Cys:
0
10
0
0
0
28
0
0
0
10
0
0
0
10
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% D
% Glu:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% E
% Phe:
10
0
10
0
28
0
0
0
0
0
0
0
0
10
10
% F
% Gly:
0
10
0
0
10
19
0
10
10
0
10
10
28
10
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
10
0
19
0
28
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
0
0
10
19
19
0
0
0
10
0
0
% K
% Leu:
0
0
10
10
0
0
19
10
0
10
0
19
0
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
10
0
0
0
28
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
0
10
0
0
0
0
10
0
0
% Q
% Arg:
10
0
10
10
0
0
10
10
10
19
19
37
10
37
37
% R
% Ser:
28
0
0
0
0
0
0
0
19
0
10
0
19
10
10
% S
% Thr:
0
0
0
0
10
10
0
0
28
0
10
0
10
0
0
% T
% Val:
0
10
0
0
0
10
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
19
0
19
37
19
10
0
28
0
28
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _